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Huey-Jen Lin, PhD
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Home > Faculty > Huey-Jen Lin, PhD
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Huey-Jen Lin, Ph.D., MT(ASCP), CLSpMB(NCA)
Assistant Professor
816 Biomedical Research Tower
460 West 12th Avenue.
Columbus, OH 43210
Phone: (614) 688-3088
Fax: (614) 688-4181
mailto:lin.661@osu.edu |
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Education
B.S. Biochemistry, Fu Jen Catholic University, (Taiwan)
M.S. Molecular Biology, National Tsing-Hua University, (Taiwan)
Ph.D. Molecular Virology, University of Delaware, (USA)
Postdoctural Molecular Oncology, Pronceton University, (USA)
Clinical Laboratory Science Internship, University of Michigan Hospital, (USA)
Certification
Specialist in Molecular Diagnosis, National Credentialing Agency for Laboratory Personnel, 2002-present
Medical Technologist (generalist), American Society for Clinical Pathology, 2003-present
Honors and Awards
Graduate Student Science and technology Scholarship, National Tsing-Hua University, 1984
Block Fellowship, University of Delaware, 1991
Outstanding Young Investigator Award, University of Michigan Department of Pediatrics, 2000
SAMP Faculty Research Award, The Ohio State University School of Allied Medical Professions, 2009
Research Interest
While the majority of breast tumor mass is of epithelial origin and cancerous, the neighboring tumor-associated fibroblasts are non-cancerous but can promote malignancy, in part by influencing epithelial cells. Tumor epithelial cells commonly harbor "silenced" tumor suppressor genes, partly due to DNA hypermethylation. To date, the mechanistic cause(s) leading to DNA hypermethylation and gene silencing remains poorly understood. My laboratory has undertaken studies to examine how tumor suppressor genes can be epigenetically silenced in breast epithelial cells, particularly the aberrant event commanded by cancer-associated fibroblasts. Further, the signaling pathways gaverning epigenomic perturbations comprised my main research streamlines. Together, this study would depict a casuyal mechanism defining how tumor-microenvirnment conveys DNA hypermethylation, leads to silencing of tumor suppressor genes in breast epitelia, and promotes breast tumorigenesis.
Courses Taught
MT 500.01 - Microbiology, Bacteriology (Lecture)
MT 600.01 - Molecular Investigations of Infectious Diseases (Lecture)
MT 600.02 - Molecular Investigations of Infectious Diseases (Lab)
Funded Grants
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01/01/2008 - 12/31/2008
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"Epigenetic influence of breast tumor-associated fibroblasts on normal mammary epithelial cells." American Cancer Society, Ohio Division. $25,000.00. Principal Investigator.
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09/01/2008 - 08/31/2011
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"Epigenetic impact of breast tumors microenvironment on normal mammary stem cells: A novel approach for developing treatment regimens and diagnostic tests." US Army, Department of Defense. $450,000.00. Principal Investigator.
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05/01/2009 - 04/30/2012
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"The epigenetic impact of cancer-associated fibroblasts on breast neoplasm." Susan G. Komen Race for the Cure. $450,000.00. Principal Investigator.
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Publications
Peer Reviewed Journal Articles
1. Wang, FF, Wang YJ, Lee, HJ, Fong, JC. "Identification of Erythropoietin Receptors of
Erythroleukemic Cells." Biochem International. Vol. 18. (1989): 163-171.
2. Lin, HJ, Upson, RH, Simmons, DT. "Nonspecific DNA Binding Activity of Simian Virus 40 Large
T Antigen: Evidence for the Cooperation of Two Regions for Full Activity." Journal of
Virology. Vol. 66. (1992): 5443-5452.
3. White, E, Chiou, SK, Rao, L, Sabbatini, P, Lin, HJ. "Control of p53-dependent Apoptosis by
E1B, Bcl-2 and H-ras Proteins." Cold Spring Harbor Symp Quant Biology. Vol. 59. (1994):
395-402.
4. Lin, HJ, Eviner, V, Prendergast, GC, White, E. "Activated H-ras Rescues E1A-induced
Apoptosis and Cooperates with E1A to Overcome p53-dependent Growth Arrest." Molecular
Cellular Biology. Vol. 15. (1995): 4536-4544.
5. Lin, HJ, Flint, SJ. "Identification of a Cellular Repressor of Transcription of the Adenoviral
Late Iva2 Gene that is Unaltered in Activity in Affected Cells." Virology. Vol. 277. (2000):
397-410.
6. Page, C, Lin, HJ, Jing, Y, Castle, VP, Nunez, G, Lin, J. "Overexpression of Akt/AKT Can
Modulate Chemotherapy-induced Apoptosis." Anticancer Res.. Vol. 20. (2000): 407-416.
7. Burke, W, Jin, X, Lin, HJ, Huang, M, Liu, R, Reynolds, RK and Lin, J. "Inhibition of
Constitutively Active Stat3 Suppresses Growth of Human Ovarian and Breast Cancer Cells."
Oncogene. Vol. 20. (2001): 7925-7934.
8. Jasty, R, Van Golen, C, Lin, HJ, Solomon, G, Heidelberger, K, Polverini, P, Opipari, A,
Feldman, E, Castl, VP. "Bcl-2 and N-Myc Coepression Increases IGF-IR and Features of
Malignant Growth in Neuroblastoma Cell Lines." Neoplasia. Vol. 3. (2001): 304-313.
9. Lin, J, Jin, X, Rothman, K, Lin, HJ, Tang, H, Burke, W. "Modulation of Signal Transducer and
Activator of Transcription 3 Activates by p53 Tumor Suppressor in Breast Cancer Cells."
Cancer Research. Vol. 62. (2002): 376-380.
10. Bian, X, Giordano, TD, Lin, HJ, Solomon, G, Castle, VP, Opipari, AW Jr. "Chemotherapy-
induced Apoptosis of S- type Neuroblastoma Cells Requires Caspase-9 and is Augmented
by CD95/Fas Stimulation." Journal of Biological Chemistry. Vol. 279. (February 2004):
4663-4669.
11. Lin, HJ, Hsieh, FC, Song, H, Lin, J. "Elevated Phosphorylation and Activation of PDK-1/AKT
Pathway in Human Breast Cancer." British Journal of Cancer. Vol. 93. (2005): 1372-
1381.
12. Cen, L, Arnoczky, KJ, Hsieh, FC, Lin, HJ, Qualman, SJ, Yu, S, Xiang, H and Lin, J.
"Phosphorylation Profiles of Protein Kinases in Alveolar and Embryonal
Rhabdomyosarcoma." Modern Pathology (Nature Publishing Group). Vol. 20. (2007): 936-
946.
13. Cen, l, Hsieh, FC, Lin, HJ, Chen, CS, Qualman, SJ and Lin, J. "PDK-1AKT Pathway as a
Novel Therapeutic Target in Rhabdomyosarcom Cells Using OSU-03012 Compound." British
Journal of Cancer (Nature Publishing Group). Vol. 97. (2007): 785-791.
14. Christina Chan, Huey-Jen Lin, and Jiayuh Lin. "Stress-associated hormone, norepinephrine, increases
proliferation and IL-6 levels of human pancreatic duct epithelial cells and can be inhibited by the dietary
agent, sulforaphane." International Journal of Oncology. Vol. 33. (2008): 415-419.
15. Lieblein JC, Ball S, Hutzen B, Sasser AK, Lin HJ, Huang THM, Hall BM, Lin J. "STAT3 Can be
Activated Through Paracrine Signaling in Breast Epithelial Cells." BMC Cancer. Vol. 8 (2008):
302-315.
16. Michael W.Y. Chan, Yi-Wen Huang, Corinna Hartman-Frey, Chieh-Ti Kuo, Daniel Deatherage, Huaxia
Qin, Alfred S.L. Cheng, Pearlly S. Yan, Ramana V. Davuluri, Tim H.-M. Huang, Kenneth P. Nephew, and
Huey-Jen Lin. "Aberrant Transforming Growth Factor-beta 1 Signaling and SMAD4 Nuclear Translocation
Confer Epigenetic Repression of ADAM19 in Ovarian Cancer." Neoplasia. Vol. 10. (2008): 1-12.
17. Lin HJ, Zuo T, Lin CH, Kuo CT, Liyanarachchi S, Sun S, Shen R, Deatherage DE, Potter D, Asamoto L,
Lin S, Yan PS, Cheng AL, Ostrowski MC, Huang THM. "Breast Cancer Associated Fibroblasts Confer
AKT1-Mediated Epigenetic Silencing of Cystatin M in Epithelial Cells." Cancer Research. Vol. 68. (2008): 10257-10266.
18. Yi-Wen Huang, Rachel A. Jansen, Enrica Fabbri, Dustin Potter, Michael W. Y. Chan, Joseph C. Liu,
Anne P.G. Crijns, Robert Brown, Kenneth P. Nephew, Ate G.J. van der Zee, David E. Cohn, Pearlly S.
Yan, Tim H.-M. Huang, Huey-Jen Lin. "Identification of candidate epigenetic biomarkers for ovarian
cancer detection." Oncology Reports. ( In Press 2009)
19. Huaxia Qin, Michael W.Y. Chan, Sandya Liyanarachchi, Curtis Balch, Dustin Potter,Irene J. Souriraj,
Alfred S.L. Cheng, Francisco J. Agosto-Perez, Elena V. Nikonova, PearllyS. Yan, Huey-Jen Lin,
Kenneth P. Nephew, Joel H. Saltz, Louise C. Showe, Tim H.- M.H. "An Integrative ChIP-chip and Gene
Expression Profiling to Model SMAD Regulatory Modules." BMC Systems Biology. Vol.3 (2009): 73-92.
20. Lin HJ, Zuo T, Chau JR, Peng Z, Asamoto L, Yamashita S, Huang THM. "Seed in Soil, with an
Epigenetic View." Biochimica et Biophysica Acta, Vol.1790 (2009): 920-924.
Editor Reviewed Journal Articles
1. Tao Zuo, Huey-Jen Lin, Michael W.Y. Chan, Alfred S.-L. Cheng, Benjamin Tycko, and Tim H.-M. Huang.
"Methods in Cancer Epigenetics." Epigenomics. ISSN 1750-1911. (In Press 2010).
Chapters In Books
1. Alfred S.-L. Cheng, Huey-Jen Lin, and Tim H.-M. Huang. "Chapter 6: Interrogating Estrogen Receptor a
Signaling in Breast Cancer by Chromatin Immunoprecipitation MicroArrays." In Genomic Endocrinology.
Edited by Stuart Handwerger and Bruce J. Aronow. 115-129. DOI: 10.1007/978-1-59745-309-7_6:
Humana Press. (2007).
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